I’ve been using this for the past two weeks:
MySQL Tuner
I’ve used on servers running on MySQL 4.0, or 5.1 lately to tweak their preformances. It’s an awesome script, and I recommend using it on any MySQL server you can find. 
Since I’ve written this post, mysqltuner has earned a permanent spot in my toolbox — if you have a project that involves a MySQL server, give it some love.
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Thanks for recommended this wonderful script, I used it for some time, and I want to say, that it is really great.